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CMap Candidate Details

Structure:
CMap ID: C05413
Pert ID: BRD-K60160658
Compound Name: tiagabine
Targets: SLC6A1
MoA: GABA uptake inhibitor
SMILES: Cc1ccsc1C(=CCCN1CCC[C@H](C1)C(O)=O)c1sccc1C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24796 BRD-K60160658 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25524 BRD-K60160658 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97168 BRD-K60160658 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123855 BRD-K60160658 A549 10 uM 24 h 0.21 0.89 0.02 -0.21 -0.72 0.04
123924 BRD-K60160658 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123973 BRD-K60160658 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124026 BRD-K60160658 JURKAT 0.125 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
124077 BRD-K60160658 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.21 -0.71 0.03
124105 BRD-K60160658 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124142 BRD-K60160658 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124207 BRD-K60160658 THP1 1.11 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
124260 BRD-K60160658 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132211 BRD-K60160658 HELA 0.74 uM 24 h 0.27 1.12 0.27 -0.24 -0.82 0.15
132313 BRD-K60160658 PC3 0.03 uM 24 h 0.24 0.99 0.1 -0.43 -1.45 15.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).