CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00542
Pert ID:	BRD-K31495718
Compound Name:	AZD7687
Targets:	DGAT1
MoA:	diacylglycerol O acyltransferase inhibitor
SMILES:	Cc1nc(C)c(nc1C(N)=O)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
121905	BRD-K31495718	A375	0.04 uM	24 h	0.0	0.0	0.0	0.34	1.21	1.13
122020	BRD-K31495718	HT29	3.33 uM	24 h	-0.23	-0.95	0.09	0.0	0.0	0.0
122068	BRD-K31495718	HUVEC	10 uM	24 h	0.0	0.0	0.0	-0.4	-1.36	2.02
122093	BRD-K31495718	MCF10A	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122118	BRD-K31495718	MCF??7.00	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130210	BRD-K31495718	A549	0.03 uM	24 h	0.0	0.0	0.0	-0.22	-0.74	0.05
130241	BRD-K31495718	HA1E	0.08 uM	24 h	0.23	0.98	0.09	-0.29	-0.98	0.48
130265	BRD-K31495718	HEK293	0.25 uM	24 h	0.22	0.9	0.03	-0.32	-1.07	0.76
130302	BRD-K31495718	HELA	0.03 uM	24 h	-0.23	-0.94	0.08	-0.33	-1.12	0.93
130369	BRD-K31495718	JURKAT	0.03 uM	24 h	-0.33	-1.38	1.09	0.28	0.98	0.37
130459	BRD-K31495718	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130483	BRD-K31495718	PC3	0.01 uM	24 h	-0.24	-1.0	0.15	-0.25	-0.84	0.18
130501	BRD-K31495718	THP1	0.08 uM	24 h	0.0	0.0	0.0	-0.32	-1.06	0.73
130536	BRD-K31495718	YAPC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary