CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05431
Pert ID:	BRD-K10845183
Compound Name:	tiludronate
Targets:	ATP6V1A\|MMP2\|PTPN1
MoA:	bone resorption inhibitor; osteoclast inhibitor
SMILES:	OP(O)(=O)C(Sc1ccc(Cl)cc1)P(O)(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
121161	BRD-K10845183	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121197	BRD-K10845183	A549	0.125 uM	24 h	0.0	0.0	0.0	-0.27	-0.9	0.28
121231	BRD-K10845183	HA1E	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121255	BRD-K10845183	HELA	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121324	BRD-K10845183	PC3	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129310	BRD-K10845183	HT29	0.03 uM	24 h	0.26	1.1	0.24	0.0	0.0	0.0
129344	BRD-K10845183	MCF??7.00	0.08 uM	24 h	0.21	0.86	0.01	0.31	1.09	0.68
129382	BRD-K10845183	YAPC	2.22 uM	24 h	0.26	1.09	0.23	0.0	0.0	0.0

Summary