CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05436
Pert ID:	BRD-A33084557
Compound Name:	tioconazole
Targets:	CYP51A1
MoA:	sterol demethylase inhibitor
SMILES:	Clc1sccc1COC(Cn1ccnc1)c1ccc(Cl)cc1Cl
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91221	BRD-A33084557	HUH7	8 uM	72 h	0.26	1.1	0.24	0.3	1.06	0.59
121908	BRD-A33084557	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121927	BRD-A33084557	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121941	BRD-A33084557	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121992	BRD-A33084557	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122022	BRD-A33084557	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122074	BRD-A33084557	HUVEC	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.6
122123	BRD-A33084557	MCF??7.00	10 uM	24 h	0.18	0.73	0.0	-0.3	-1.0	0.55
122175	BRD-A33084557	PC3	10 uM	24 h	0.27	1.11	0.25	0.0	0.0	0.0
122204	BRD-A33084557	THP1	10 uM	24 h	-0.21	-0.88	0.03	0.3	1.06	0.61
122226	BRD-A33084557	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130270	BRD-A33084557	HEK293	0.01 uM	24 h	0.21	0.89	0.02	-0.33	-1.11	0.92
130375	BRD-A33084557	JURKAT	2.22 uM	24 h	0.24	0.98	0.09	0.0	0.0	0.0
130418	BRD-A33084557	MCF10A	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130465	BRD-A33084557	MDAMB231	0.03 uM	24 h	0.0	0.0	0.0	0.26	0.92	0.24

Summary