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CMap Candidate Details

Structure:
CMap ID: C05443
Pert ID: BRD-K11973162
Compound Name: tipiracil
Targets: TYMP
MoA: thymidine phosphorylase inhibitor
SMILES: Clc1c(CN2CCCC2=N)[nH]c(=O)[nH]c1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122231 BRD-K11973162 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.69
122325 BRD-K11973162 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122349 BRD-K11973162 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.92
122430 BRD-K11973162 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122453 BRD-K11973162 THP1 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
122503 BRD-K11973162 YAPC 1.11 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
130545 BRD-K11973162 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130576 BRD-K11973162 HA1E 0.74 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
130607 BRD-K11973162 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130686 BRD-K11973162 HT29 0.03 uM 24 h 0.23 0.94 0.06 -0.37 -1.25 1.35
130753 BRD-K11973162 MCF??7.00 0.01 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
130771 BRD-K11973162 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).