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CMap Candidate Details

Structure:
CMap ID: C05449
Pert ID: BRD-K92968657
Compound Name: tirapazamine
Targets:
MoA: DNA inhibitor
SMILES: Nc1n[n+]([O-])c2ccccc2[n+]1[O-]
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128373 BRD-K92968657 A549 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.66
128422 BRD-K92968657 HEK293 10 uM 24 h -0.2 -0.83 0.0 -0.46 -1.54 15.35
128532 BRD-K92968657 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128585 BRD-K92968657 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128625 BRD-K92968657 MDAMB231 0.125 uM 24 h 0.25 1.05 0.17 -0.32 -1.09 0.83
128705 BRD-K92968657 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128755 BRD-K92968657 YAPC 0.37 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
136166 BRD-K92968657 A375 0.74 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
136211 BRD-K92968657 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136252 BRD-K92968657 HELA 0.03 uM 24 h 0.3 1.27 0.58 0.0 0.0 0.0
136285 BRD-K92968657 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
136333 BRD-K92968657 MCF??7.00 0.03 uM 24 h 0.26 1.09 0.24 0.0 0.0 0.0
136358 BRD-K92968657 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).