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CMap Candidate Details

Structure:
CMap ID: C05456
Pert ID: BRD-K06335600
Compound Name: tizanidine
Targets: ADRA2A|ADRA2B|ADRA2C|NISCH
MoA: adrenergic receptor agonist
SMILES: Clc1ccc2nsnc2c1NC1=NCCN1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
50330 BRD-K06335600 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
51004 BRD-K06335600 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90920 BRD-K06335600 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
122577 BRD-K06335600 A549 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.02
122601 BRD-K06335600 HA1E 10 uM 24 h -0.25 -1.06 0.26 0.0 0.0 0.0
122720 BRD-K06335600 MCF10A 0.37 uM 24 h -0.2 -0.82 0.0 -0.16 -0.55 0.0
122753 BRD-K06335600 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122792 BRD-K06335600 PC3 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
130866 BRD-K06335600 A375 0.08 uM 24 h -0.28 -1.18 0.51 0.0 0.0 0.0
130935 BRD-K06335600 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130966 BRD-K06335600 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130999 BRD-K06335600 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131042 BRD-K06335600 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.38
131118 BRD-K06335600 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131184 BRD-K06335600 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).