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CMap Candidate Details

Structure:
CMap ID: C00546
Pert ID: BRD-K37687095
Compound Name: AZD8330
Targets:
MoA: MEK inhibitor
SMILES: Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)n(C)c1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92018 BRD-K37687095 BT20 3.33 uM 24 h -0.16 -0.66 0.0 0.0 0.0 0.0
92098 BRD-K37687095 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92137 BRD-K37687095 HS578T 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92254 BRD-K37687095 MCF??7.00 0.12 uM 24 h -0.16 -0.69 0.0 -0.26 -0.87 0.24
92288 BRD-K37687095 MDAMB231 0.12 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
92365 BRD-K37687095 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95302 BRD-K37687095 A549 10 uM 24 h 0.23 0.96 0.08 0.31 1.08 0.67
95417 BRD-K37687095 U2OS 10 uM 48 h 0.22 0.9 0.02 0.34 1.19 1.01
97329 BRD-K37687095 HAP1 0.66 uM 24 h -0.3 -1.27 0.74 0.0 0.0 0.0
123524 BRD-K37687095 A375 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.76
123591 BRD-K37687095 HEK293 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.69
123627 BRD-K37687095 HELA 10 uM 24 h 0.0 0.0 0.0 0.38 1.36 1.72
123706 BRD-K37687095 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123747 BRD-K37687095 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132021 BRD-K37687095 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132064 BRD-K37687095 HT29 0.25 uM 24 h -0.15 -0.63 0.0 0.0 0.0 0.0
132148 BRD-K37687095 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.34 1.22 1.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).