Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C05472
Pert ID: BRD-K32164935
Compound Name: tolazamide
Targets: ABCC8|KCNJ1|KCNJ10|KCNJ11
MoA: ATP channel blocker
SMILES: Cc1ccc(cc1)S(=O)(=O)NC(=O)NN1CCCCCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4096 BRD-K32164935 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4921 BRD-K32164935 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
9197 BRD-K32164935 A549 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.09 0.82
9407 BRD-K32164935 AGS 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.47
10145 BRD-K32164935 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10501 BRD-K32164935 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11469 BRD-K32164935 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11748 BRD-K32164935 NCIH508 10 uM 6 h -0.2 -0.85 0.01 0.0 0.0 0.0
12032 BRD-K32164935 NCIH596 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.67
12303 BRD-K32164935 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12463 BRD-K32164935 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
13257 BRD-K32164935 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44921 BRD-K32164935 ASC 10 uM 24 h 0.2 0.85 0.01 -0.18 -0.59 0.0
45803 BRD-K32164935 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.09 0.82
46675 BRD-K32164935 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52738 BRD-K32164935 HEPG2 4 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.31
53234 BRD-K32164935 MCF10A 100 uM 24 h 0.0 0.0 0.0 0.2 0.71 0.02
91108 BRD-K32164935 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
98805 BRD-K32164935 NPC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
98887 BRD-K32164935 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99841 BRD-K32164935 U2OS 15 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.58
121903 BRD-K32164935 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121967 BRD-K32164935 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
122066 BRD-K32164935 HUVEC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130300 BRD-K32164935 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130326 BRD-K32164935 HT29 0.25 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
130367 BRD-K32164935 JURKAT 0.03 uM 24 h 0.21 0.87 0.01 -0.32 -1.08 0.79
130458 BRD-K32164935 MDAMB231 0.25 uM 24 h -0.31 -1.27 0.74 0.0 0.0 0.0
130500 BRD-K32164935 THP1 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130534 BRD-K32164935 YAPC 2.22 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).