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CMap Candidate Details

Structure:
CMap ID: C05474
Pert ID: BRD-K85119730
Compound Name: tolbutamide
Targets: ABCC8|KCNJ1|KCNJ11|KCNJ8
MoA: ATP channel blocker
SMILES: CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4967 BRD-K85119730 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37195 BRD-K85119730 A375 10 uM 6 h -0.24 -0.99 0.13 0.0 0.0 0.0
37751 BRD-K85119730 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38566 BRD-K85119730 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38786 BRD-K85119730 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50422 BRD-K85119730 HCC515 10 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.37
52983 BRD-K85119730 HEPG2 40 uM 3 h 0.28 1.17 0.36 0.0 0.0 0.0
90951 BRD-K85119730 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
126060 BRD-K85119730 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126146 BRD-K85119730 JURKAT 3.33 uM 24 h -0.29 -1.23 0.62 0.0 0.0 0.0
126199 BRD-K85119730 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.44
126317 BRD-K85119730 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134048 BRD-K85119730 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134075 BRD-K85119730 HA1E 0.74 uM 24 h -0.22 -0.92 0.06 -0.38 -1.28 1.45
134120 BRD-K85119730 HEK293 0.08 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
134162 BRD-K85119730 HELA 0.08 uM 24 h 0.27 1.11 0.26 0.0 0.0 0.0
134211 BRD-K85119730 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.43 1.54 2.3
134240 BRD-K85119730 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134273 BRD-K85119730 MDAMB231 0.01 uM 24 h -0.28 -1.18 0.51 0.0 0.0 0.0
134296 BRD-K85119730 PC3 0.74 uM 24 h 0.24 1.0 0.1 -0.34 -1.15 1.06
134325 BRD-K85119730 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).