CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05476
Pert ID:	BRD-K50133271
Compound Name:	tolfenamic-acid
Targets:
MoA:	cyclooxygenase inhibitor; prostanoid receptor antagonist
SMILES:	Cc1c(Cl)cccc1Nc1ccccc1C(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91250	BRD-K50133271	HUH7	12.5 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
99611	BRD-K50133271	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
125593	BRD-K50133271	A375	0.04 uM	24 h	0.22	0.92	0.04	0.0	0.0	0.0
125677	BRD-K50133271	HELA	0.125 uM	24 h	0.2	0.83	0.0	-0.22	-0.73	0.05
125746	BRD-K50133271	HUVEC	1.11 uM	24 h	0.0	0.0	0.0	-0.27	-0.92	0.33
125832	BRD-K50133271	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125855	BRD-K50133271	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125879	BRD-K50133271	PC3	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.89	0.27
125899	BRD-K50133271	THP1	0.125 uM	24 h	0.25	1.06	0.18	0.0	0.0	0.0
125944	BRD-K50133271	YAPC	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133672	BRD-K50133271	A549	0.03 uM	24 h	0.0	0.0	0.0	-0.35	-1.18	1.14
133708	BRD-K50133271	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.29	1.02	0.48
133738	BRD-K50133271	HEK293	2.22 uM	24 h	0.0	0.0	0.0	-0.42	-1.4	2.02
133805	BRD-K50133271	HT29	0.03 uM	24 h	0.32	1.31	0.78	0.0	0.0	0.0
133831	BRD-K50133271	JURKAT	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133864	BRD-K50133271	MCF10A	0.25 uM	24 h	0.0	0.0	0.0	0.28	0.98	0.36

Summary