CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00548
Pert ID:	BRD-K98572433
Compound Name:	AZD8931
Targets:	EGFR\|ERBB2\|ERBB3
MoA:	EGFR inhibitor
SMILES:	CNC(=O)CN1CCC(CC1)Oc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
128118	BRD-K98572433	A375	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.41
128148	BRD-K98572433	A549	10 uM	24 h	0.24	0.98	0.09	0.27	0.95	0.31
128173	BRD-K98572433	HEK293	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128191	BRD-K98572433	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128237	BRD-K98572433	MCF10A	0.37 uM	24 h	0.0	0.0	0.0	0.22	0.79	0.07
128267	BRD-K98572433	MCF??7.00	10 uM	24 h	0.23	0.95	0.06	0.0	0.0	0.0
128316	BRD-K98572433	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128338	BRD-K98572433	PC3	10 uM	24 h	-0.23	-0.96	0.1	0.0	0.0	0.0
128360	BRD-K98572433	THP1	1.11 uM	24 h	0.0	0.0	0.0	-0.33	-1.11	0.91
135821	BRD-K98572433	HA1E	0.03 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.31
135910	BRD-K98572433	HELA	0.74 uM	24 h	0.17	0.7	0.0	0.0	0.0	0.0
136000	BRD-K98572433	JURKAT	2.22 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.45
136146	BRD-K98572433	YAPC	2.22 uM	24 h	-0.2	-0.82	0.0	-0.27	-0.91	0.29

Summary