CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05487
Pert ID:	BRD-A82035391
Compound Name:	tolvaptan
Targets:	AVPR1A\|AVPR2
MoA:	vasopressin receptor antagonist
SMILES:	Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc23)c(C)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
126369	BRD-A82035391	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126391	BRD-A82035391	A549	10 uM	24 h	-0.29	-1.22	0.6	0.38	1.33	1.72
126460	BRD-A82035391	HEK293	3.33 uM	24 h	0.0	0.0	0.0	-0.38	-1.29	1.53
126503	BRD-A82035391	HT29	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126544	BRD-A82035391	MCF??7.00	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126564	BRD-A82035391	MDAMB231	10 uM	24 h	-0.23	-0.96	0.09	0.0	0.0	0.0
134414	BRD-A82035391	HA1E	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134443	BRD-A82035391	HELA	0.08 uM	24 h	-0.24	-1.0	0.15	0.0	0.0	0.0
134527	BRD-A82035391	HUVEC	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134553	BRD-A82035391	MCF10A	0.25 uM	24 h	-0.2	-0.85	0.01	0.28	0.98	0.37
134638	BRD-A82035391	PC3	2.22 uM	24 h	0.26	1.09	0.23	0.0	0.0	0.0
134663	BRD-A82035391	YAPC	0.08 uM	24 h	0.0	0.0	0.0	-0.27	-0.9	0.29

Summary