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CMap Candidate Details

Structure:
CMap ID: C05489
Pert ID: BRD-K36970462
Compound Name: tonabersat
Targets:
MoA: gap junction modulator; nitric oxide production inhibitor
SMILES: CC(=O)c1ccc2OC(C)(C)[C@@H](O)[C@@H](NC(=O)c3ccc(F)c(Cl)c3)c2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121757 BRD-K36970462 HELA 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
121787 BRD-K36970462 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121817 BRD-K36970462 MCF??7.00 1.11 uM 24 h -0.18 -0.75 0.0 -0.29 -0.98 0.47
121837 BRD-K36970462 PC3 10 uM 24 h 0.0 0.0 0.0 0.35 1.26 1.29
121865 BRD-K36970462 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.06
129751 BRD-K36970462 A375 0.74 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
129783 BRD-K36970462 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.26 0.94 0.28
129816 BRD-K36970462 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129911 BRD-K36970462 JURKAT 0.25 uM 24 h -0.27 -1.13 0.4 0.0 0.0 0.0
129943 BRD-K36970462 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130027 BRD-K36970462 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130099 BRD-K36970462 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.38 1.33 1.72
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).