CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05490
Pert ID:	BRD-K29653726
Compound Name:	topiramate
Targets:	CA1\|CA12\|CA2\|CA4\|CA7\|GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6\|GABRB1\|GABRB2\|GABRB3\|GABRD\|GABRE\|GABRG1\|GABRG2\|GABRG3\|GABRP\|GABRQ\|GRIA1\|GRIA2\|GRIA3\|GRIA4\|GRIK1\|GRIK2\|GRIK3\|GRIK4\|GRIK5\|SCN10A\|SCN11A\|SCN1A\|SCN2A\|SCN3A\|SCN4A\|SCN5A\|SCN7A\|SCN8A\|SCN9A
MoA:	carbonic anhydrase inhibitor; glutamate receptor antagonist; kainate receptor antagonist
SMILES:	CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1428	BRD-K29653726	NPC	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
24891	BRD-K29653726	HT29	10 uM	6 h	0.21	0.88	0.01	-0.31	-1.06	0.72
25349	BRD-K29653726	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119999	BRD-K29653726	A549	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120158	BRD-K29653726	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0	-0.25	-0.83	0.16
128798	BRD-K29653726	A375	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128818	BRD-K29653726	HA1E	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128830	BRD-K29653726	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128851	BRD-K29653726	PC3	0.74 uM	24 h	-0.27	-1.11	0.36	0.3	1.05	0.56
128880	BRD-K29653726	YAPC	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary