CMap Candidate Details
Structure:
| CMap ID: | C05491 |
| Pert ID: | BRD-K77561571 |
| Compound Name: | topiroxostat |
| Targets: | XDH |
| MoA: | xanthine oxidase inhibitor |
| SMILES: | N#Cc1cc(ccn1)-c1n[nH]c(n1)-c1ccncc1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 127364 | BRD-K77561571 | A375 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127401 | BRD-K77561571 | A549 | 0.04 uM | 24 h | -0.26 | -1.08 | 0.28 | 0.0 | 0.0 | 0.0 |
| 127440 | BRD-K77561571 | HA1E | 1.11 uM | 24 h | -0.19 | -0.78 | 0.0 | -0.17 | -0.58 | 0.0 |
| 127474 | BRD-K77561571 | HELA | 0.125 uM | 24 h | -0.36 | -1.48 | 1.43 | 0.23 | 0.81 | 0.08 |
| 127530 | BRD-K77561571 | JURKAT | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.28 | 0.98 | 0.37 |
| 127581 | BRD-K77561571 | MCF??7.00 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.31 | 1.08 | 0.66 |
| 127619 | BRD-K77561571 | PC3 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127657 | BRD-K77561571 | THP1 | 0.04 uM | 24 h | -0.2 | -0.85 | 0.01 | 0.0 | 0.0 | 0.0 |
| 127703 | BRD-K77561571 | YAPC | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 135415 | BRD-K77561571 | HT29 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 135447 | BRD-K77561571 | MCF10A | 0.03 uM | 24 h | 0.32 | 1.32 | 0.82 | 0.0 | 0.0 | 0.0 |