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CMap Candidate Details

Structure:
CMap ID: C05492
Pert ID: BRD-K55696337
Compound Name: topotecan
Targets: TOP1|TOP1MT
MoA: topoisomerase inhibitor
SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1429 BRD-K55696337 NPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24685 BRD-K55696337 A549 10 uM 6 h -0.34 -1.44 1.43 0.0 0.0 0.0
24924 BRD-K55696337 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25032 BRD-K55696337 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91229 BRD-K55696337 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
96036 BRD-K55696337 PHH 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118382 BRD-K55696337 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118453 BRD-K55696337 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118493 BRD-K55696337 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118539 BRD-K55696337 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118648 BRD-K55696337 PC3 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).