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CMap Candidate Details

Structure:
CMap ID: C05496
Pert ID: BRD-K51350053
Compound Name: toremifene
Targets: ESR1
MoA: estrogen receptor antagonist; selective estrogen receptor modulator (SERM)
SMILES: CN(C)CCOc1ccc(cc1)C(\c1ccccc1)=C(\CCCl)c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5787 BRD-K51350053 HCC515 10 uM 6 h 0.0 0.0 0.0 0.25 0.9 0.21
6565 BRD-K51350053 VCAP 10 uM 6 h 0.0 0.0 0.0 0.38 1.33 1.72
23078 BRD-K51350053 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37294 BRD-K51350053 A549 10 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
37683 BRD-K51350053 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38506 BRD-K51350053 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38741 BRD-K51350053 PHH 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.08
38968 BRD-K51350053 SKB 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
91231 BRD-K51350053 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
121557 BRD-K51350053 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121596 BRD-K51350053 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121634 BRD-K51350053 HELA 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.2
121658 BRD-K51350053 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121677 BRD-K51350053 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121701 BRD-K51350053 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129687 BRD-K51350053 PC3 0.74 uM 24 h -0.36 -1.49 1.43 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).