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CMap Candidate Details

Structure:
CMap ID: C05499
Pert ID: BRD-K92241597
Compound Name: tosedostat
Targets: ANPEP|LAP3|NPEPPS
MoA: peptidase inhibitor
SMILES: CC(C)C[C@H]([C@H](O)C(=O)NO)C(=O)N[C@H](C(=O)OC1CCCC1)c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9544 BRD-K92241597 AGS 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9851 BRD-K92241597 H1299 80 uM 6 h 0.0 0.0 0.0 -0.48 -1.61 15.65
10249 BRD-K92241597 HCC515 80 uM 6 h 0.21 0.88 0.01 -0.23 -0.78 0.09
10625 BRD-K92241597 HCT116 80 uM 6 h 0.0 0.0 0.0 -0.4 -1.36 2.02
11611 BRD-K92241597 NCIH2073 80 uM 6 h -0.16 -0.66 0.0 0.0 0.0 0.0
12167 BRD-K92241597 NCIH596 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12405 BRD-K92241597 NOMO1 80 uM 6 h 0.0 0.0 0.0 -0.28 -0.94 0.37
12900 BRD-K92241597 SW480 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13395 BRD-K92241597 U937 80 uM 6 h 0.0 0.0 0.0 0.17 0.6 0.0
13514 BRD-K92241597 VCAP 80 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
118408 BRD-K92241597 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.99
118563 BRD-K92241597 HEPG2 10 uM 24 h 0.16 0.68 0.0 -0.44 -1.48 15.35
118668 BRD-K92241597 PC3 10 uM 24 h 0.25 1.05 0.16 0.0 0.0 0.0
127385 BRD-K92241597 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127417 BRD-K92241597 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127459 BRD-K92241597 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127505 BRD-K92241597 JURKAT 10 uM 24 h 0.19 0.78 0.0 0.28 0.98 0.38
127551 BRD-K92241597 MCF10A 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
127675 BRD-K92241597 YAPC 0.04 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
135394 BRD-K92241597 HT29 2.22 uM 24 h 0.26 1.08 0.21 -0.31 -1.05 0.72
135466 BRD-K92241597 MCF??7.00 2.22 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
135493 BRD-K92241597 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.21 0.73 0.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).