CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00551
Pert ID:	BRD-K31476763
Compound Name:	AZD9668
Targets:	ELANE
MoA:	elastase inhibitor
SMILES:	Cc1c(cc(C(=O)NCc2ccc(cn2)S(C)(=O)=O)c(=O)n1-c1cccc(c1)C(F)(F)F)-c1ccnn1C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
121906	BRD-K31476763	A375	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121924	BRD-K31476763	A549	3.33 uM	24 h	0.2	0.84	0.0	0.0	0.0	0.0
121969	BRD-K31476763	HEK293	0.04 uM	24 h	0.0	0.0	0.0	-0.35	-1.17	1.14
122069	BRD-K31476763	HUVEC	1.11 uM	24 h	0.0	0.0	0.0	0.3	1.06	0.58
122119	BRD-K31476763	MCF??7.00	10 uM	24 h	0.25	1.05	0.16	-0.27	-0.92	0.34
122173	BRD-K31476763	PC3	0.04 uM	24 h	0.0	0.0	0.0	0.3	1.07	0.63
122224	BRD-K31476763	YAPC	0.04 uM	24 h	0.26	1.09	0.23	0.0	0.0	0.0
130242	BRD-K31476763	HA1E	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130303	BRD-K31476763	HELA	0.25 uM	24 h	0.0	0.0	0.0	0.31	1.11	0.71
130327	BRD-K31476763	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.33	1.17	0.93
130370	BRD-K31476763	JURKAT	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130413	BRD-K31476763	MCF10A	0.08 uM	24 h	0.0	0.0	0.0	0.37	1.32	1.62
130460	BRD-K31476763	MDAMB231	0.74 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.67
130502	BRD-K31476763	THP1	0.25 uM	24 h	-0.35	-1.45	1.43	0.0	0.0	0.0

Summary