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CMap Candidate Details

Structure:
CMap ID: C05523
Pert ID: BRD-K69837166
Compound Name: trap-101
Targets: OPRL1
MoA: nociceptin/orphanin FQ receptor antagonist; opioid receptor antagonist
SMILES: CCn1c2ccccc2n(C2=C(CO)CN(CC3CCCCCCC3)CC2)c1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4240 BRD-K69837166 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4590 BRD-K69837166 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4711 BRD-K69837166 PC3 10 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
5115 BRD-K69837166 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.41 -1.37 2.02
39165 BRD-K69837166 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39478 BRD-K69837166 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39750 BRD-K69837166 ASC 10 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.12
40043 BRD-K69837166 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40632 BRD-K69837166 MCF??7.00 10 uM 6 h 0.19 0.78 0.0 -0.21 -0.72 0.04
41167 BRD-K69837166 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41505 BRD-K69837166 SKB 10 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
99401 BRD-K69837166 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).