CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05524
Pert ID:	BRD-K95763993
Compound Name:	trapidil
Targets:	PDGFRA
MoA:	PDGFR tyrosine kinase receptor inhibitor
SMILES:	CCN(CC)c1cc(C)nc2ncnn12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
3297	BRD-K95763993	HCC515	10 uM	24 h	0.0	0.0	0.0	0.25	0.9	0.21
3994	BRD-K95763993	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
39853	BRD-K95763993	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40141	BRD-K95763993	HEPG2	10 uM	6 h	0.24	1.0	0.1	0.0	0.0	0.0
40948	BRD-K95763993	NEU	10 uM	24 h	-0.23	-0.96	0.1	-0.4	-1.35	2.01
41274	BRD-K95763993	NPC	10 uM	24 h	0.0	0.0	0.0	-0.38	-1.28	1.45
41615	BRD-K95763993	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
52216	BRD-K95763993	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
128105	BRD-K95763993	A375	1.11 uM	24 h	-0.19	-0.81	0.0	0.27	0.97	0.35
128132	BRD-K95763993	A549	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128212	BRD-K95763993	MCF10A	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128291	BRD-K95763993	MDAMB231	0.04 uM	24 h	0.3	1.24	0.53	-0.28	-0.93	0.34
128349	BRD-K95763993	THP1	10 uM	24 h	0.19	0.8	0.0	0.21	0.76	0.05
135801	BRD-K95763993	HA1E	0.74 uM	24 h	0.0	0.0	0.0	-0.19	-0.64	0.01
135845	BRD-K95763993	HEK293	0.03 uM	24 h	0.0	0.0	0.0	0.25	0.88	0.19
135886	BRD-K95763993	HELA	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135934	BRD-K95763993	HT29	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135975	BRD-K95763993	JURKAT	0.74 uM	24 h	0.0	0.0	0.0	-0.41	-1.38	2.02
136052	BRD-K95763993	PC3	0.01 uM	24 h	0.17	0.71	0.0	0.0	0.0	0.0
136121	BRD-K95763993	YAPC	0.01 uM	24 h	0.0	0.0	0.0	0.35	1.23	1.19

Summary