Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C00553
Pert ID: BRD-A68888262
Compound Name: azelastine
Targets: HRH1
MoA: histamine receptor antagonist
SMILES: CN1CCCC(CC1)n1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25304 BRD-A68888262 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51683 BRD-A68888262 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
100293 BRD-A68888262 U2OS 10 uM 6 h 0.25 1.04 0.15 0.34 1.19 1.03
126624 BRD-A68888262 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126668 BRD-A68888262 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126765 BRD-A68888262 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.12
126798 BRD-A68888262 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.19 0.68 0.01
126875 BRD-A68888262 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126937 BRD-A68888262 THP1 10 uM 24 h -0.18 -0.74 0.0 -0.27 -0.9 0.28
126985 BRD-A68888262 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134694 BRD-A68888262 A549 0.25 uM 24 h -0.2 -0.85 0.01 0.28 1.0 0.42
134757 BRD-A68888262 HEK293 0.03 uM 24 h 0.28 1.15 0.33 0.0 0.0 0.0
134790 BRD-A68888262 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134819 BRD-A68888262 HT29 0.25 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
134852 BRD-A68888262 HUVEC 0.74 uM 24 h 0.2 0.84 0.0 0.23 0.83 0.11
134958 BRD-A68888262 PC3 2.22 uM 24 h 0.28 1.17 0.36 -0.3 -1.02 0.61
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).