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CMap Candidate Details

Structure:
CMap ID: C05584
Pert ID: BRD-A13084692
Compound Name: troglitazone
Targets: ACSL4|ESRRA|ESRRG|PPARG|SERPINE1|SLC29A1|TRPM3
MoA: insulin sensitizer; PPAR receptor agonist
SMILES: Cc1c(C)c2OC(C)(COc3ccc(CC4SC(=O)NC4=O)cc3)CCc2c(C)c1O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1251 BRD-A13084692 A549 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1447 BRD-A13084692 NPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9268 BRD-A13084692 AGS 10 uM 6 h -0.25 -1.03 0.19 0.31 1.11 0.72
9571 BRD-A13084692 H1299 10 uM 6 h -0.26 -1.1 0.35 -0.22 -0.72 0.04
10383 BRD-A13084692 HCT116 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.76 0.07
11321 BRD-A13084692 NCIH2073 10 uM 6 h -0.21 -0.86 0.02 0.0 0.0 0.0
11639 BRD-A13084692 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11891 BRD-A13084692 NCIH596 10 uM 6 h 0.22 0.91 0.03 0.0 0.0 0.0
12647 BRD-A13084692 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13023 BRD-A13084692 THP1 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.94 0.38
83545 BRD-A13084692 HA1E 20 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.06
84760 BRD-A13084692 MCF??7.00 20 uM 24 h -0.21 -0.89 0.03 -0.42 -1.42 2.02
88149 BRD-A13084692 VCAP 0.37 uM 24 h 0.0 0.0 0.0 -0.19 -0.63 0.01
88988 BRD-A13084692 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90434 BRD-A13084692 HL60 10 uM 2 h -0.2 -0.84 0.01 0.0 0.0 0.0
90756 BRD-A13084692 HPTEC 3.33 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.38
90971 BRD-A13084692 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
98968 BRD-A13084692 NEU 10 uM 6 h 0.19 0.78 0.0 -0.32 -1.06 0.73
100173 BRD-A13084692 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
116793 BRD-A13084692 HCC515 10 uM 24 h 0.17 0.71 0.0 -0.27 -0.92 0.32
117553 BRD-A13084692 HT29 10 uM 24 h 0.24 1.0 0.11 -0.32 -1.08 0.8
117670 BRD-A13084692 A375 10 uM 24 h -0.28 -1.15 0.44 -0.29 -0.99 0.5
118558 BRD-A13084692 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119739 BRD-A13084692 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.22
122414 BRD-A13084692 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
130621 BRD-A13084692 HEK293 0.01 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
130662 BRD-A13084692 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.49
130739 BRD-A13084692 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.18 0.63 0.0
130832 BRD-A13084692 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.26 0.94 0.28
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).