CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05594
Pert ID:	BRD-K00494077
Compound Name:	trovafloxacin
Targets:	TOP2A
MoA:	bacterial DNA gyrase inhibitor
SMILES:	N[C@H]1[C@@H]2CN(C[C@H]12)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)-c1ccc(F)cc1F
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
122845	BRD-K00494077	A549	10 uM	24 h	0.0	0.0	0.0	0.21	0.74	0.03
122853	BRD-K00494077	HA1E	10 uM	24 h	0.27	1.11	0.25	-0.24	-0.82	0.15
122877	BRD-K00494077	HEK293	10 uM	24 h	0.29	1.2	0.43	0.0	0.0	0.0
122929	BRD-K00494077	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122961	BRD-K00494077	HT29	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.12	0.95
123002	BRD-K00494077	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123053	BRD-K00494077	MCF10A	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.07	0.75
123071	BRD-K00494077	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123091	BRD-K00494077	MDAMB231	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123163	BRD-K00494077	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131200	BRD-K00494077	A375	2.22 uM	24 h	0.28	1.18	0.4	0.0	0.0	0.0
131339	BRD-K00494077	HUVEC	2.22 uM	24 h	-0.18	-0.75	0.0	0.0	0.0	0.0
131452	BRD-K00494077	PC3	2.22 uM	24 h	0.26	1.07	0.2	0.0	0.0	0.0
131482	BRD-K00494077	YAPC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary