CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05607
Pert ID:	BRD-K99621550
Compound Name:	tubocurarine
Targets:	ACHE\|CHRNA2\|HTR3A\|HTR3B\|KCNN1\|KCNN2\|KCNN3\|ZACN
MoA:	acetylcholine receptor antagonist
SMILES:	COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5c(O)c(OC)cc6CC[N+](C)(C)[C@H](Cc7ccc(O)c(Oc1cc23)c7)c56)cc4
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5243	BRD-K99621550	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
5382	BRD-K99621550	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
5706	BRD-K99621550	HCC515	10 uM	24 h	0.0	0.0	0.0	0.38	1.34	1.72
5967	BRD-K99621550	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
6117	BRD-K99621550	MCF??7.00	10 uM	6 h	-0.3	-1.26	0.72	0.0	0.0	0.0
6228	BRD-K99621550	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
6609	BRD-K99621550	VCAP	10 uM	6 h	0.0	0.0	0.0	0.21	0.75	0.04
39387	BRD-K99621550	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39873	BRD-K99621550	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40416	BRD-K99621550	HT29	10 uM	6 h	0.0	0.0	0.0	-0.4	-1.34	1.85
40967	BRD-K99621550	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41291	BRD-K99621550	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41636	BRD-K99621550	SKB	10 uM	24 h	0.18	0.77	0.0	0.0	0.0	0.0
90940	BRD-K99621550	HUH7	6.66 uM	72 h	0.0	0.0	0.0	-0.24	-0.81	0.13

Summary