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CMap Candidate Details

Structure:
CMap ID: C05613
Pert ID: BRD-K94176593
Compound Name: TWS-119
Targets: GSK3B|JUN|MYC
MoA: glycogen synthase kinase inhibitor
SMILES: Nc1cccc(c1)-c1cc2c(Oc3cccc(O)c3)ncnc2[nH]1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1793 BRD-K94176593 HA1E 10 uM 6 h 0.0 0.0 0.0 0.42 1.47 2.24
2145 BRD-K94176593 HCC515 10 uM 6 h 0.24 0.99 0.09 0.39 1.37 2.06
2155 BRD-K94176593 PC3 10 uM 24 h -0.23 -0.95 0.08 -0.27 -0.9 0.29
41988 BRD-K94176593 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42498 BRD-K94176593 ASC 10 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
42808 BRD-K94176593 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.06 0.73
43095 BRD-K94176593 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43673 BRD-K94176593 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43974 BRD-K94176593 PHH 10 uM 24 h 0.23 0.95 0.07 0.0 0.0 0.0
44220 BRD-K94176593 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90344 BRD-K94176593 VCAP 15 uM 24 h 0.28 1.16 0.35 0.27 0.97 0.35
91857 BRD-K94176593 MCF??7.00 10 uM 24 h 0.26 1.07 0.19 0.22 0.76 0.05
91903 BRD-K94176593 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.72 0.04
92002 BRD-K94176593 A375 10 uM 24 h 0.27 1.14 0.31 0.0 0.0 0.0
92028 BRD-K94176593 BT20 3.33 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.24
92167 BRD-K94176593 HS578T 10 uM 3 h 0.0 0.0 0.0 0.37 1.33 1.71
92219 BRD-K94176593 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92374 BRD-K94176593 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97582 BRD-K94176593 NKDBA 4 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99108 BRD-K94176593 NEU 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).