Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C05623
Pert ID: BRD-K87919739
Compound Name: tyrphostin-AG-825
Targets: ERBB2
MoA: protein tyrosine kinase inhibitor
SMILES: COc1cc(\C=C(/C#N)C(N)=O)cc(CSc2nc3ccccc3s2)c1O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3064 BRD-K87919739 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3279 BRD-K87919739 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3646 BRD-K87919739 PC3 10 uM 6 h 0.21 0.88 0.02 0.0 0.0 0.0
3885 BRD-K87919739 VCAP 10 uM 24 h 0.0 0.0 0.0 0.16 0.57 0.0
44456 BRD-K87919739 A375 10 uM 6 h 0.22 0.92 0.04 0.0 0.0 0.0
44626 BRD-K87919739 A549 10 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.8
45044 BRD-K87919739 ASC 10 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
45332 BRD-K87919739 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45591 BRD-K87919739 HT29 10 uM 6 h 0.19 0.8 0.0 -0.35 -1.17 1.13
45855 BRD-K87919739 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46156 BRD-K87919739 NPC 10 uM 24 h 0.28 1.16 0.35 0.0 0.0 0.0
46469 BRD-K87919739 PHH 10 uM 24 h 0.28 1.17 0.36 0.0 0.0 0.0
46797 BRD-K87919739 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).