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CMap Candidate Details

Structure:
CMap ID: C05648
Pert ID: BRD-K57011718
Compound Name: UK-356618
Targets: MMP13|MMP14|MMP2|MMP3|MMP9
MoA: metalloproteinase inhibitor
SMILES: C[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCc1ccc(c(C)c1)-c1ccccc1)CC(=O)NO)C(C)(C)C)c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9107 BRD-K57011718 A549 10 uM 24 h -0.27 -1.13 0.41 0.18 0.64 0.0
9453 BRD-K57011718 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9759 BRD-K57011718 H1299 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.86 0.21
9878 BRD-K57011718 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10123 BRD-K57011718 HCC515 10 uM 24 h -0.21 -0.88 0.03 -0.35 -1.17 1.13
10808 BRD-K57011718 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.62
11057 BRD-K57011718 HT29 10 uM 6 h -0.28 -1.16 0.45 -0.36 -1.21 1.24
11136 BRD-K57011718 MCF??7.00 10 uM 24 h 0.17 0.71 0.0 0.0 0.0 0.0
11518 BRD-K57011718 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11788 BRD-K57011718 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12081 BRD-K57011718 NCIH596 10 uM 6 h -0.18 -0.75 0.0 0.0 0.0 0.0
12819 BRD-K57011718 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13306 BRD-K57011718 U937 10 uM 6 h 0.22 0.93 0.05 0.0 0.0 0.0
13641 BRD-K57011718 VCAP 10 uM 6 h 0.22 0.91 0.03 -0.31 -1.06 0.72
96753 BRD-K57011718 A375 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.49
96808 BRD-K57011718 PC3 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).