CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05675
Pert ID:	BRD-K73196317
Compound Name:	urapidil
Targets:	HTR1A
MoA:	adrenergic receptor antagonist
SMILES:	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
25415	BRD-K73196317	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
52191	BRD-K73196317	MCF??7.00	10 uM	6 h	0.24	1.0	0.11	-0.26	-0.89	0.26
52331	BRD-K73196317	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99442	BRD-K73196317	U2OS	10 uM	6 h	-0.23	-0.96	0.1	-0.33	-1.12	0.95
126383	BRD-K73196317	A549	0.125 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.45
126444	BRD-K73196317	HEK293	0.04 uM	24 h	0.0	0.0	0.0	0.23	0.83	0.12
126479	BRD-K73196317	HELA	0.37 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.26
126607	BRD-K73196317	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134352	BRD-K73196317	A375	2.22 uM	24 h	-0.29	-1.19	0.53	0.0	0.0	0.0
134403	BRD-K73196317	HA1E	2.22 uM	24 h	0.0	0.0	0.0	-0.37	-1.25	1.35
134467	BRD-K73196317	HT29	0.08 uM	24 h	0.2	0.82	0.0	-0.26	-0.89	0.26
134510	BRD-K73196317	HUVEC	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134543	BRD-K73196317	MCF10A	0.03 uM	24 h	0.25	1.06	0.18	0.0	0.0	0.0
134603	BRD-K73196317	MDAMB231	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary