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CMap Candidate Details

Structure:
CMap ID: C05686
Pert ID: BRD-K68185022
Compound Name: ursolic-acid
Targets: HSD11B1|PLA2G1B|PTPN1|PYGM
MoA: ATPase inhibitor; NFkB pathway inhibitor; STAT inhibitor
SMILES: C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8970 BRD-K68185022 A375 70 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9111 BRD-K68185022 A549 70 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9483 BRD-K68185022 AGS 70 uM 6 h 0.32 1.34 0.89 0.36 1.26 1.29
9788 BRD-K68185022 H1299 70 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10073 BRD-K68185022 HA1E 70 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10153 BRD-K68185022 HCC515 70 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10570 BRD-K68185022 HCT116 70 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10828 BRD-K68185022 HEPG2 70 uM 6 h 0.22 0.91 0.04 0.41 1.44 2.21
11002 BRD-K68185022 HT29 70 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11164 BRD-K68185022 MCF??7.00 70 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11549 BRD-K68185022 NCIH2073 70 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11815 BRD-K68185022 NCIH508 70 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12107 BRD-K68185022 NCIH596 70 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12477 BRD-K68185022 PC3 70 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12846 BRD-K68185022 SW480 70 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12994 BRD-K68185022 THP1 70 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13334 BRD-K68185022 U937 70 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.25
13495 BRD-K68185022 VCAP 70 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
97482 BRD-K68185022 NKDBA 25 uM 24 h 0.0 0.0 0.0 -0.2 -0.69 0.02
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).