CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05703
Pert ID:	BRD-K77625799
Compound Name:	vandetanib
Targets:	EGFR\|EPHA1\|EPHA10\|EPHA2\|EPHA3\|EPHA4\|EPHA5\|EPHA6\|EPHA7\|EPHA8\|EPHB1\|EPHB2\|EPHB3\|EPHB4\|EPHB6\|ERBB2\|ERBB3\|ERBB4\|FLT1\|FLT4\|KDR\|PTK6\|RET\|SRC\|TEK\|VEGFA
MoA:	EGFR inhibitor; RET tyrosine kinase inhibitor; VEGFR inhibitor
SMILES:	COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1213	BRD-K77625799	PC3	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.83	0.17
1339	BRD-K77625799	U2OS	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92883	BRD-K77625799	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92967	BRD-K77625799	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93024	BRD-K77625799	CD34	10 uM	24 h	0.34	1.42	1.08	0.0	0.0	0.0
93109	BRD-K77625799	HEK293	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93192	BRD-K77625799	HEPG2	10 uM	24 h	-0.23	-0.96	0.1	0.0	0.0	0.0
93250	BRD-K77625799	HUVEC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93300	BRD-K77625799	JURKAT	10 uM	24 h	0.26	1.07	0.19	0.0	0.0	0.0
93378	BRD-K77625799	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.35	1.26	1.29
93434	BRD-K77625799	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93523	BRD-K77625799	SKL	10 uM	24 h	-0.21	-0.87	0.02	0.34	1.21	1.15
117134	BRD-K77625799	HCC515	1.11 uM	24 h	-0.28	-1.17	0.49	-0.27	-0.91	0.31
127400	BRD-K77625799	A549	3.33 uM	24 h	-0.33	-1.36	1.06	0.36	1.28	1.37
127438	BRD-K77625799	HA1E	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127473	BRD-K77625799	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127562	BRD-K77625799	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127580	BRD-K77625799	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.62
127655	BRD-K77625799	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127700	BRD-K77625799	YAPC	10 uM	24 h	0.0	0.0	0.0	0.33	1.18	0.98
135414	BRD-K77625799	HT29	0.74 uM	24 h	0.0	0.0	0.0	0.33	1.18	0.98

Summary