CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05708
Pert ID:	BRD-K13926615
Compound Name:	vardenafil
Targets:	PDE5A\|PDE6G\|PDE6H
MoA:	phosphodiesterase inhibitor
SMILES:	CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4367	BRD-K13926615	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
4898	BRD-K13926615	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
22989	BRD-K13926615	HEPG2	10 uM	6 h	0.21	0.89	0.02	-0.29	-0.97	0.47
37599	BRD-K13926615	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38432	BRD-K13926615	NPC	10 uM	24 h	0.0	0.0	0.0	-0.22	-0.73	0.05
91084	BRD-K13926615	HUH7	6.66 uM	72 h	0.0	0.0	0.0	-0.26	-0.87	0.22
96716	BRD-K13926615	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122344	BRD-K13926615	HT29	0.04 uM	24 h	-0.24	-1.0	0.15	-0.26	-0.88	0.24
122390	BRD-K13926615	MCF??7.00	0.125 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.68
122420	BRD-K13926615	MDAMB231	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122478	BRD-K13926615	THP1	10 uM	24 h	-0.24	-1.01	0.15	0.0	0.0	0.0
130558	BRD-K13926615	A549	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130593	BRD-K13926615	HA1E	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130627	BRD-K13926615	HEK293	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130670	BRD-K13926615	HELA	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130741	BRD-K13926615	MCF10A	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130814	BRD-K13926615	PC3	0.74 uM	24 h	0.0	0.0	0.0	0.33	1.16	0.9
130839	BRD-K13926615	YAPC	0.08 uM	24 h	-0.28	-1.15	0.44	0.0	0.0	0.0

Summary