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CMap Candidate Details

Structure:
CMap ID: C05715
Pert ID: BRD-K26756394
Compound Name: VE-821
Targets: ATR
MoA: ATR kinase inhibitor
SMILES: CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
93633 BRD-K26756394 A549 10 uM 24 h 0.22 0.91 0.04 -0.35 -1.18 1.14
93676 BRD-K26756394 ASC 1.11 uM 24 h 0.27 1.14 0.32 -0.2 -0.68 0.02
93741 BRD-K26756394 CD34 10 uM 24 h 0.32 1.32 0.82 0.0 0.0 0.0
93775 BRD-K26756394 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93815 BRD-K26756394 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93866 BRD-K26756394 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93906 BRD-K26756394 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93948 BRD-K26756394 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
94003 BRD-K26756394 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
94049 BRD-K26756394 JURKAT 0.04 uM 24 h -0.29 -1.2 0.56 -0.38 -1.27 1.41
94078 BRD-K26756394 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94129 BRD-K26756394 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94166 BRD-K26756394 NPC 10 uM 24 h 0.21 0.86 0.01 -0.31 -1.06 0.72
94209 BRD-K26756394 PC3 3.33 uM 24 h 0.24 1.0 0.1 0.0 0.0 0.0
94264 BRD-K26756394 SHSY5Y 10 uM 24 h -0.38 -1.56 1.43 0.0 0.0 0.0
94315 BRD-K26756394 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94359 BRD-K26756394 THP1 0.04 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.21
94397 BRD-K26756394 YAPC 0.12 uM 24 h 0.22 0.91 0.03 -0.24 -0.79 0.11
96721 BRD-K26756394 A375 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).