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CMap Candidate Details

Structure:
CMap ID: C05722
Pert ID: BRD-K62391742
Compound Name: venetoclax
Targets: BCL2
MoA: BCL inhibitor
SMILES: CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1199 BRD-K62391742 PC3 10 uM 24 h 0.22 0.9 0.02 -0.24 -0.8 0.11
1349 BRD-K62391742 U2OS 10 uM 48 h 0.0 0.0 0.0 -0.36 -1.22 1.25
87292 BRD-K62391742 BJAB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87374 BRD-K62391742 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87424 BRD-K62391742 K562 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.47
87471 BRD-K62391742 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87509 BRD-K62391742 MINO 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87576 BRD-K62391742 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87626 BRD-K62391742 OCILY10 0.125 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
87676 BRD-K62391742 OCILY19 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87727 BRD-K62391742 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87775 BRD-K62391742 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87857 BRD-K62391742 TMD8 10 uM 3 h 0.28 1.18 0.39 0.0 0.0 0.0
124594 BRD-K62391742 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124613 BRD-K62391742 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.3
124689 BRD-K62391742 HT29 10 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
124758 BRD-K62391742 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124875 BRD-K62391742 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124912 BRD-K62391742 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132660 BRD-K62391742 A375 2.22 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.43
132748 BRD-K62391742 HEK293 2.22 uM 24 h -0.18 -0.75 0.0 -0.29 -0.99 0.5
132786 BRD-K62391742 HELA 0.74 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.27
132831 BRD-K62391742 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.39
132865 BRD-K62391742 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132915 BRD-K62391742 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).