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CMap Candidate Details

Structure:
CMap ID: C05723
Pert ID: BRD-A51714012
Compound Name: venlafaxine
Targets: SLC6A2|SLC6A3|SLC6A4
MoA: adrenergic inhibitor; norepinephrine reuptake inhibitor; serotonin norepinephrine reuptake inhibitor (SNRI)
SMILES: COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5526 BRD-A51714012 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5844 BRD-A51714012 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6383 BRD-A51714012 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37514 BRD-A51714012 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38363 BRD-A51714012 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38646 BRD-A51714012 PHH 10 uM 24 h -0.27 -1.14 0.42 -0.29 -0.97 0.46
51567 BRD-A51714012 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91287 BRD-A51714012 HUH7 12 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
100206 BRD-A51714012 U2OS 10 uM 6 h -0.24 -1.01 0.16 0.0 0.0 0.0
124295 BRD-A51714012 HA1E 0.125 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
124313 BRD-A51714012 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124342 BRD-A51714012 HELA 10 uM 24 h 0.0 0.0 0.0 0.35 1.23 1.19
124403 BRD-A51714012 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124480 BRD-A51714012 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124536 BRD-A51714012 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132322 BRD-A51714012 A375 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132351 BRD-A51714012 A549 0.01 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
132456 BRD-A51714012 HT29 0.01 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
132486 BRD-A51714012 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132568 BRD-A51714012 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132591 BRD-A51714012 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).