CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05726
Pert ID:	BRD-A09533288
Compound Name:	verapamil
Targets:	CACNA1A\|CACNA1B\|CACNA1C\|CACNA1D\|CACNA1F\|CACNA1G\|CACNA1I\|CACNA1S\|CACNB1\|CACNB2\|CACNB3\|CACNB4\|CYP3A4\|KCNA10\|KCNA7\|KCNH2\|KCNJ11\|NALCN\|SCN5A\|SLC29A4\|SLC6A4
MoA:	calcium channel blocker
SMILES:	COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1431	BRD-A09533288	NPC	12.5 uM	24 h	0.0	0.0	0.0	-0.32	-1.07	0.78
9264	BRD-A09533288	AGS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
9567	BRD-A09533288	H1299	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
10158	BRD-A09533288	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
10380	BRD-A09533288	HCT116	10 uM	6 h	0.28	1.15	0.32	0.0	0.0	0.0
10649	BRD-A09533288	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11317	BRD-A09533288	NCIH2073	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11636	BRD-A09533288	NCIH508	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11887	BRD-A09533288	NCIH596	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
12644	BRD-A09533288	SW480	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13126	BRD-A09533288	U937	10 uM	6 h	0.21	0.88	0.01	0.0	0.0	0.0
13522	BRD-A09533288	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
44473	BRD-A09533288	A549	10 uM	24 h	-0.26	-1.07	0.27	-0.25	-0.85	0.19
44744	BRD-A09533288	ASC	10 uM	24 h	0.0	0.0	0.0	0.31	1.08	0.66
46176	BRD-A09533288	PHH	10 uM	24 h	0.23	0.95	0.06	0.0	0.0	0.0
46492	BRD-A09533288	SKB	10 uM	24 h	0.0	0.0	0.0	0.32	1.12	0.76
91038	BRD-A09533288	HUH7	8 uM	72 h	-0.29	-1.21	0.58	-0.28	-0.95	0.4
98967	BRD-A09533288	NEU	10 uM	6 h	-0.26	-1.09	0.33	0.0	0.0	0.0
121155	BRD-A09533288	A375	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121290	BRD-A09533288	MCF??7.00	1.11 uM	24 h	0.38	1.59	1.52	0.3	1.08	0.65
121321	BRD-A09533288	PC3	0.04 uM	24 h	0.31	1.28	0.61	0.0	0.0	0.0
121350	BRD-A09533288	YAPC	10 uM	24 h	0.29	1.22	0.48	-0.38	-1.29	1.57
129256	BRD-A09533288	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129264	BRD-A09533288	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129304	BRD-A09533288	HT29	2.22 uM	24 h	0.25	1.04	0.15	0.0	0.0	0.0

Summary