CMap Candidate Details
Structure:
| CMap ID: | C05736 |
| Pert ID: | BRD-K84748119 |
| Compound Name: | vicriviroc |
| Targets: | CCR5 |
| MoA: | CC chemokine receptor antagonist |
| SMILES: | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 125583 | BRD-K84748119 | A375 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.96 | 0.43 |
| 125735 | BRD-K84748119 | HUVEC | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.33 | -1.11 | 0.9 |
| 125778 | BRD-K84748119 | JURKAT | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.26 | 0.92 | 0.25 |
| 125828 | BRD-K84748119 | MCF??7.00 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125851 | BRD-K84748119 | MDAMB231 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125875 | BRD-K84748119 | PC3 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125894 | BRD-K84748119 | THP1 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125933 | BRD-K84748119 | YAPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 133668 | BRD-K84748119 | A549 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.19 | 0.69 | 0.01 |
| 133699 | BRD-K84748119 | HA1E | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 133731 | BRD-K84748119 | HEK293 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 133767 | BRD-K84748119 | HELA | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.27 | 0.94 | 0.3 |
| 133800 | BRD-K84748119 | HT29 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.34 | 1.22 | 1.15 |
| 133857 | BRD-K84748119 | MCF10A | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.36 | -1.22 | 1.24 |