CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05744
Pert ID:	BRD-K40227168
Compound Name:	vinburnine
Targets:	CHRM1\|CHRM2\|CHRM3\|CHRM4
MoA:	adrenergic receptor antagonist
SMILES:	CC[C@@]12CCCN3CCc4c([C@H]13)n(C(=O)C2)c1ccccc41
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
6744	BRD-K40227168	A375	10 uM	24 h	0.31	1.3	0.73	0.0	0.0	0.0
7441	BRD-K40227168	HA1E	10 uM	6 h	0.0	0.0	0.0	-0.27	-0.9	0.29
8670	BRD-K40227168	VCAP	10 uM	24 h	0.24	1.02	0.12	0.0	0.0	0.0
123310	BRD-K40227168	HELA	6.66 uM	24 h	0.0	0.0	0.0	-0.48	-1.62	15.65
123338	BRD-K40227168	HT29	6.66 uM	24 h	0.25	1.06	0.18	-0.26	-0.86	0.22
123380	BRD-K40227168	MCF??7.00	6.66 uM	24 h	0.0	0.0	0.0	-0.36	-1.21	1.24
123419	BRD-K40227168	PC3	0.03 uM	24 h	-0.27	-1.1	0.36	0.0	0.0	0.0
123456	BRD-K40227168	THP1	6.66 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123492	BRD-K40227168	YAPC	6.66 uM	24 h	0.0	0.0	0.0	-0.32	-1.09	0.81
131547	BRD-K40227168	A549	0.02 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
131624	BRD-K40227168	HEK293	1.67 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131720	BRD-K40227168	HUVEC	0.02 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131773	BRD-K40227168	JURKAT	1.67 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131820	BRD-K40227168	MCF10A	1.67 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.68
131889	BRD-K40227168	MDAMB231	0.06 uM	24 h	-0.25	-1.05	0.24	0.0	0.0	0.0

Summary