CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05753
Pert ID:	BRD-K44827188
Compound Name:	vismodegib
Targets:	SMO
MoA:	hedgehog pathway inhibitor; smoothened receptor antagonist
SMILES:	Clc1cc(ccc1C(=O)Nc1ccc(Cl)c(c1)-c1ccccn1)S(C)(=O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
96452	BRD-K44827188	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
118804	BRD-K44827188	HCC515	1.11 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.55
118846	BRD-K44827188	HEPG2	3.33 uM	24 h	-0.32	-1.31	0.82	0.0	0.0	0.0
118959	BRD-K44827188	PC3	0.12 uM	24 h	-0.29	-1.21	0.6	0.32	1.12	0.76
124607	BRD-K44827188	HA1E	10 uM	24 h	0.0	0.0	0.0	0.35	1.24	1.28
124680	BRD-K44827188	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124715	BRD-K44827188	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124752	BRD-K44827188	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124781	BRD-K44827188	MDAMB231	0.37 uM	24 h	-0.22	-0.9	0.04	-0.31	-1.06	0.72
132679	BRD-K44827188	A549	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132740	BRD-K44827188	HEK293	0.03 uM	24 h	0.0	0.0	0.0	-0.26	-0.89	0.27
132781	BRD-K44827188	HELA	2.22 uM	24 h	0.25	1.03	0.13	0.0	0.0	0.0
132858	BRD-K44827188	MCF10A	0.25 uM	24 h	-0.26	-1.09	0.31	0.0	0.0	0.0
132924	BRD-K44827188	THP1	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132943	BRD-K44827188	YAPC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary