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CMap Candidate Details

Structure:
CMap ID: C05759
Pert ID: BRD-K69776681
Compound Name: volasertib
Targets: PLK1
MoA: PLK inhibitor
SMILES: CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90850 BRD-K69776681 MCF10A 1.11 uM 12 h 0.0 0.0 0.0 0.0 0.0 0.0
117016 BRD-K69776681 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117056 BRD-K69776681 A549 3.33 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
117138 BRD-K69776681 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
117183 BRD-K69776681 HEPG2 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117231 BRD-K69776681 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
117268 BRD-K69776681 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126775 BRD-K69776681 JURKAT 3.33 uM 24 h 0.21 0.88 0.01 -0.26 -0.87 0.22
126947 BRD-K69776681 THP1 1.11 uM 24 h 0.16 0.68 0.0 -0.33 -1.1 0.86
126992 BRD-K69776681 YAPC 1.11 uM 24 h 0.28 1.16 0.35 0.0 0.0 0.0
134726 BRD-K69776681 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
134763 BRD-K69776681 HEK293 2.22 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
134795 BRD-K69776681 HELA 2.22 uM 24 h 0.21 0.87 0.01 -0.32 -1.07 0.75
134862 BRD-K69776681 HUVEC 0.74 uM 24 h -0.17 -0.72 0.0 0.0 0.0 0.0
134941 BRD-K69776681 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134962 BRD-K69776681 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).