Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C05765
Pert ID: BRD-K81418486
Compound Name: vorinostat
Targets: HDAC1|HDAC10|HDAC11|HDAC2|HDAC3|HDAC5|HDAC6|HDAC8|HDAC9
MoA: HDAC inhibitor
SMILES: ONC(=O)CCCCCCC(=O)Nc1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
36 BRD-K81418486 SKBR3 0.66 uM 24 h 0.17 0.73 0.0 -0.3 -1.01 0.56
122 BRD-K81418486 K562 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
216 BRD-K81418486 NALM6 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
441 BRD-K81418486 TMD8 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
678 BRD-K81418486 MINO 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
760 BRD-K81418486 OCILY19 0.04 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
867 BRD-K81418486 SKMEL5 0.66 uM 24 h 0.0 0.0 0.0 0.37 1.32 1.62
1350 BRD-K81418486 U2OS 1.11 uM 48 h 0.0 0.0 0.0 -0.3 -1.0 0.53
9518 BRD-K81418486 AGS 12 uM 6 h 0.0 0.0 0.0 -0.32 -1.09 0.81
9823 BRD-K81418486 H1299 12 uM 6 h -0.23 -0.97 0.1 0.0 0.0 0.0
10604 BRD-K81418486 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11584 BRD-K81418486 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11847 BRD-K81418486 NCIH508 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12143 BRD-K81418486 NCIH596 12 uM 6 h -0.19 -0.79 0.0 -0.25 -0.86 0.2
12388 BRD-K81418486 NOMO1 12 uM 6 h -0.21 -0.85 0.01 0.0 0.0 0.0
12876 BRD-K81418486 SW480 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13368 BRD-K81418486 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38782 BRD-K81418486 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39009 BRD-K81418486 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52573 BRD-K81418486 HEPG2 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53165 BRD-K81418486 MCF10A 1.11 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
53536 BRD-K81418486 HUH7 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
67560 BRD-K81418486 A375 0.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
69523 BRD-K81418486 MCF??7.00 0.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
80341 BRD-K81418486 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87331 BRD-K81418486 BJAB 0.04 uM 6 h 0.0 0.0 0.0 -0.22 -0.75 0.06
87375 BRD-K81418486 HBL1 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87472 BRD-K81418486 KMS34 0.04 uM 24 h 0.31 1.29 0.64 0.38 1.36 1.73
87627 BRD-K81418486 OCILY10 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87728 BRD-K81418486 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87795 BRD-K81418486 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
88884 BRD-K81418486 VCAP 2.22 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
89141 BRD-K81418486 PC3 0.37 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.91
92968 BRD-K81418486 CD34 10 uM 24 h 0.41 1.71 1.69 0.0 0.0 0.0
93194 BRD-K81418486 HUVEC 10 uM 24 h 0.25 1.03 0.13 0.0 0.0 0.0
93337 BRD-K81418486 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93466 BRD-K81418486 SKL 10 uM 24 h -0.16 -0.68 0.0 0.0 0.0 0.0
93565 BRD-K81418486 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93836 BRD-K81418486 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94466 BRD-K81418486 ASC 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
94666 BRD-K81418486 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94714 BRD-K81418486 HME1 10 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
94864 BRD-K81418486 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94991 BRD-K81418486 NEU 10 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
95085 BRD-K81418486 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97277 BRD-K81418486 HAP1 0.66 uM 24 h -0.23 -0.97 0.11 -0.22 -0.75 0.06
97494 BRD-K81418486 NKDBA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118820 BRD-K81418486 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119216 BRD-K81418486 A549 0.04 uM 24 h -0.21 -0.88 0.03 -0.28 -0.94 0.39
119244 BRD-K81418486 HA1E 0.37 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.11
136444 BRD-K81418486 SHSY5Y 0.125 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).