CMap Candidate Details
Structure:
| CMap ID: | C05766 |
| Pert ID: | BRD-K53963539 |
| Compound Name: | vortioxetine |
| Targets: | HTR1A|HTR1B|HTR2A|HTR2C|HTR3A|HTR5A|HTR6|HTR7|SLC6A4 |
| MoA: | serotonin receptor agonist; serotonin receptor antagonist |
| SMILES: | Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 124275 | BRD-K53963539 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124287 | BRD-K53963539 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.37 | 1.32 | 1.71 |
| 124301 | BRD-K53963539 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124319 | BRD-K53963539 | HEK293 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124354 | BRD-K53963539 | HELA | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124385 | BRD-K53963539 | HT29 | 10 uM | 24 h | 0.23 | 0.97 | 0.08 | -0.28 | -0.94 | 0.36 |
| 124420 | BRD-K53963539 | JURKAT | 0.125 uM | 24 h | -0.26 | -1.08 | 0.29 | -0.27 | -0.92 | 0.33 |
| 124450 | BRD-K53963539 | MCF10A | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124467 | BRD-K53963539 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.3 | -1.02 | 0.62 |
| 124489 | BRD-K53963539 | MDAMB231 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.34 | 1.19 | 1.03 |
| 124519 | BRD-K53963539 | PC3 | 10 uM | 24 h | 0.21 | 0.87 | 0.01 | 0.0 | 0.0 | 0.0 |
| 124549 | BRD-K53963539 | YAPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 132608 | BRD-K53963539 | THP1 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.24 | 0.86 | 0.16 |