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CMap Candidate Details

Structure:
CMap ID: C05770
Pert ID: BRD-K72005722
Compound Name: VT-464
Targets: CYP17A1
MoA: cytochrome P450 inhibitor
SMILES: CC(C)[C@@](O)(c1c[nH]nn1)c1ccc2cc(OC(F)F)c(OC(F)F)cc2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126637 BRD-K72005722 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126658 BRD-K72005722 A549 10 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
126787 BRD-K72005722 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126856 BRD-K72005722 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126900 BRD-K72005722 MDAMB231 3.33 uM 24 h -0.2 -0.83 0.0 -0.26 -0.87 0.23
126969 BRD-K72005722 THP1 3.33 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
127003 BRD-K72005722 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134743 BRD-K72005722 HA1E 0.01 uM 24 h 0.0 0.0 0.0 -0.2 -0.67 0.01
134777 BRD-K72005722 HEK293 0.01 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
134806 BRD-K72005722 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134835 BRD-K72005722 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134883 BRD-K72005722 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134934 BRD-K72005722 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.96
134972 BRD-K72005722 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).