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CMap Candidate Details

Structure:
CMap ID: C05790
Pert ID: BRD-K93725829
Compound Name: VX-11e
Targets: MAPK1
MoA: MAP kinase inhibitor
SMILES: Cc1cnc(Nc2ccc(F)cc2Cl)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1cccc(Cl)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9057 BRD-K93725829 A375 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9128 BRD-K93725829 A549 0.5 uM 24 h 0.25 1.06 0.18 0.26 0.94 0.28
9550 BRD-K93725829 AGS 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9858 BRD-K93725829 H1299 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9977 BRD-K93725829 HA1E 0.5 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
10344 BRD-K93725829 HCC515 0.5 uM 6 h -0.23 -0.95 0.09 0.36 1.27 1.34
10632 BRD-K93725829 HCT116 0.5 uM 6 h 0.0 0.0 0.0 0.36 1.28 1.37
10883 BRD-K93725829 HEPG2 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11043 BRD-K93725829 HT29 0.5 uM 24 h -0.19 -0.81 0.0 0.42 1.47 2.24
11227 BRD-K93725829 MCF??7.00 0.5 uM 24 h 0.0 0.0 0.0 0.39 1.37 1.97
11618 BRD-K93725829 NCIH2073 0.5 uM 6 h 0.23 0.98 0.09 0.0 0.0 0.0
11875 BRD-K93725829 NCIH508 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12175 BRD-K93725829 NCIH596 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12412 BRD-K93725829 NOMO1 0.5 uM 6 h 0.0 0.0 0.0 0.28 0.99 0.41
12553 BRD-K93725829 PC3 0.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12907 BRD-K93725829 SW480 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13080 BRD-K93725829 THP1 0.5 uM 6 h -0.2 -0.85 0.01 0.0 0.0 0.0
13400 BRD-K93725829 U937 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13708 BRD-K93725829 VCAP 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).