CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05792
Pert ID:	BRD-K07736136
Compound Name:	VX-702
Targets:	MAPK11\|MAPK12\|MAPK14
MoA:	p38 MAPK inhibitor
SMILES:	NC(=O)N(c1ccc(C(N)=O)c(n1)-c1ccc(F)cc1F)c1c(F)cccc1F
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
33772	BRD-K07736136	A549	10 uM	24 h	0.0	0.0	0.0	-0.49	-1.64	15.65
34037	BRD-K07736136	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
34309	BRD-K07736136	HA1E	10 uM	6 h	-0.24	-1.0	0.14	0.27	0.94	0.29
34551	BRD-K07736136	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
34820	BRD-K07736136	HEPG2	10 uM	6 h	-0.28	-1.18	0.51	-0.28	-0.94	0.39
35087	BRD-K07736136	HT29	10 uM	6 h	-0.21	-0.89	0.03	0.0	0.0	0.0
35294	BRD-K07736136	MCF??7.00	10 uM	24 h	-0.26	-1.07	0.27	-0.4	-1.34	1.85
35536	BRD-K07736136	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
35722	BRD-K07736136	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
35928	BRD-K07736136	PC3	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.69
36195	BRD-K07736136	PHH	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.81
36488	BRD-K07736136	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36945	BRD-K07736136	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.27	-0.9	0.28
97280	BRD-K07736136	HAP1	0.66 uM	24 h	0.0	0.0	0.0	-0.38	-1.28	1.45
97356	BRD-K07736136	A375	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary