CMap Candidate Details
Structure:
| CMap ID: | C05794 |
| Pert ID: | BRD-K26712974 |
| Compound Name: | VX-765 |
| Targets: | CASP1 |
| MoA: | caspase inhibitor |
| SMILES: | CCO[C@H]1OC(=O)C[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(N)c(Cl)c1)C(C)(C)C |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 119979 | BRD-K26712974 | A549 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.35 | 1.24 | 1.24 |
| 120095 | BRD-K26712974 | HT29 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120139 | BRD-K26712974 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128792 | BRD-K26712974 | A375 | 0.74 uM | 24 h | 0.3 | 1.26 | 0.56 | 0.23 | 0.81 | 0.08 |
| 128809 | BRD-K26712974 | HA1E | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.87 | 0.23 |
| 128835 | BRD-K26712974 | HELA | 0.03 uM | 3 h | -0.21 | -0.87 | 0.02 | 0.0 | 0.0 | 0.0 |
| 128844 | BRD-K26712974 | PC3 | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.32 | -1.07 | 0.75 |
| 128864 | BRD-K26712974 | YAPC | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.88 | 0.25 |