CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05827
Pert ID:	BRD-K77008974
Compound Name:	WYE-354
Targets:	MTOR
MoA:	mTOR inhibitor
SMILES:	COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
33708	BRD-K77008974	A375	10 uM	6 h	0.18	0.76	0.0	-0.19	-0.63	0.01
33927	BRD-K77008974	A549	10 uM	6 h	-0.29	-1.21	0.59	0.0	0.0	0.0
34175	BRD-K77008974	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
34417	BRD-K77008974	HA1E	10 uM	6 h	0.0	0.0	0.0	-0.28	-0.96	0.42
34681	BRD-K77008974	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.16	-0.54	0.0
34956	BRD-K77008974	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.34	-1.14	1.02
35198	BRD-K77008974	HT29	10 uM	6 h	-0.24	-0.99	0.13	0.0	0.0	0.0
35344	BRD-K77008974	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.86	0.21
35617	BRD-K77008974	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
35837	BRD-K77008974	NPC	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.87
36101	BRD-K77008974	PC3	10 uM	6 h	0.0	0.0	0.0	-0.23	-0.78	0.1
36643	BRD-K77008974	SKB	10 uM	24 h	-0.33	-1.37	1.08	0.0	0.0	0.0
36866	BRD-K77008974	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.19	-0.63	0.01
95976	BRD-K77008974	PHH	3.33 uM	24 h	0.0	0.0	0.0	-0.35	-1.19	1.15

Summary