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CMap Candidate Details

Structure:
CMap ID: C05851
Pert ID: BRD-A03506276
Compound Name: XL888
Targets:
MoA: HSP inhibitor
SMILES: CC[C@@H](C)Nc1cc(C(=O)NC2CC3CCC(C2)N3c2ccc(cn2)C(=O)C2CC2)c(C)cc1C(N)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1156 BRD-A03506276 MCF??7.00 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1258 BRD-A03506276 A549 10 uM 48 h 0.0 0.0 0.0 0.27 0.95 0.31
1403 BRD-A03506276 U2OS 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
122613 BRD-A03506276 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122691 BRD-A03506276 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
122761 BRD-A03506276 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122781 BRD-A03506276 PC3 0.04 uM 24 h 0.26 1.09 0.23 0.0 0.0 0.0
130852 BRD-A03506276 A375 0.08 uM 24 h 0.18 0.76 0.0 0.29 1.03 0.51
130894 BRD-A03506276 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130944 BRD-A03506276 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130985 BRD-A03506276 HT29 0.25 uM 24 h -0.21 -0.89 0.03 0.0 0.0 0.0
131012 BRD-A03506276 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131162 BRD-A03506276 YAPC 2.22 uM 24 h -0.24 -0.98 0.13 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).