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CMap Candidate Details

Structure:
CMap ID: C05853
Pert ID: BRD-K50387473
Compound Name: XMD8-92
Targets: DCLK2|MAPK7|PLK4|TNK1
MoA: MAP kinase inhibitor
SMILES: CCOc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)N1CCC(O)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
34376 BRD-K50387473 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34902 BRD-K50387473 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36580 BRD-K50387473 SKB 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.34
36831 BRD-K50387473 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
91809 BRD-K50387473 HS578T 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91893 BRD-K50387473 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91962 BRD-K50387473 SKBR3 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
94400 BRD-K50387473 A375 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
94432 BRD-K50387473 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94467 BRD-K50387473 ASC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.13 0.97
94524 BRD-K50387473 CD34 10 uM 24 h 0.27 1.11 0.26 -0.34 -1.15 1.06
94580 BRD-K50387473 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94619 BRD-K50387473 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.49 -1.65 15.65
94669 BRD-K50387473 HELA 10 uM 24 h 0.25 1.03 0.14 0.32 1.14 0.86
94717 BRD-K50387473 HME1 10 uM 24 h 0.25 1.04 0.15 -0.29 -0.98 0.48
94775 BRD-K50387473 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94812 BRD-K50387473 HUVEC 10 uM 24 h 0.21 0.86 0.01 -0.25 -0.85 0.2
94866 BRD-K50387473 JURKAT 10 uM 24 h 0.26 1.08 0.21 -0.26 -0.87 0.23
94918 BRD-K50387473 MCF10A 3.33 uM 24 h -0.21 -0.87 0.02 -0.28 -0.95 0.41
94961 BRD-K50387473 MCF??7.00 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
94993 BRD-K50387473 NEU 10 uM 24 h -0.23 -0.97 0.11 0.3 1.05 0.56
95044 BRD-K50387473 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95100 BRD-K50387473 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
95137 BRD-K50387473 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
95192 BRD-K50387473 SKL 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.66
95251 BRD-K50387473 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96007 BRD-K50387473 PHH 10 uM 24 h 0.21 0.89 0.02 -0.34 -1.15 1.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).